Autistic measure 5X more likely if low vitamin D in second trimester – Oct 2012

Maternal Vitamin D Levels and the Autism Phenotype Among Offspring.

J Autism Dev Disord. 2012 Oct 16.
Whitehouse AJ, Holt BJ, Serralha M, Holt PG, Hart PH, Kusel MM.
Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, 100 Roberts Road, Subiaco, West Perth, WA, 6008, Australia, awhitehouse at ichr.uwa.edu.au.

We tested whether maternal vitamin D insufficiency during pregnancy is related to the autism phenotype. Serum 25(OH)-vitamin D concentrations of 929 women were measured at 18 weeks' pregnancy. The mothers of the three children with a clinical diagnosis of autism spectrum disorder had 25(OH)-vitamin D concentrations above the population mean.

The offspring of 406 women completed the Autism-Spectrum Quotient in early adulthood. Maternal 25(OH)-vitamin D concentrations were unrelated to offspring scores on the majority of scales.

However, offspring of mothers with low 25(OH)-vitamin D concentrations (<49 nmol/L) were at increased risk for 'high' scores (?2SD above mean) on the Attention Switching subscale (odds ratio: 5.46, 95 % confidence interval: 1.29, 23.05). The involvement of maternal vitamin D during pregnancy in autism requires continued investigation.

PMID: 23070790

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See also VitaminDWiki

• Overview Autism and vitamin D
• All articles in Autism category 163 items
• Low vitamin D in pregnancy and 2X worse language skills later – Feb 2012
• Autism treated by Vitamin D: Dr. Cannell - video June 2013
• Prenatal vitamins – including vitamin D – reduced autism by 7X in some cases – May 2011
• Autism 4 times more likely if low vitamin D during first trimester – Oct 2016

See also web

• Autism-Spectrum Quotient in Wikipedia
  social skills; communication skills; imagination; attention to detail; and attention switching/tolerance of change.